Profluent

What is Profluent?

Profluent is an AI-driven biotech company that designs novel proteins using artificial intelligence, with a mission of authoring new biology for medicine and agriculture. It describes OpenCRISPR as the world's first AI-designed gene editor. It is a research and partnership company rather than a self-serve software product.

Key capabilities of Profluent

• Protein language models: AI models trained on protein sequences to generate new proteins
• OpenCRISPR: AI-designed gene editors
• AI-designed recombinases: proteins for genetic medicine, part of the Eli Lilly partnership
• Protein design: generates new protein sequences for therapeutic and other uses
• Open model releases: publishes some models to the research community
• Drug discovery partnerships: collaborations to design medicines with pharma partners

How Profluent works

Profluent trains large AI models on biological sequence data and uses them to generate protein candidates with desired functions, then validates promising designs in the lab. Outputs such as gene editors are tested experimentally by scientists before any therapeutic use, so human researchers and wet-lab validation remain central.

Who uses Profluent?

Pharmaceutical and biotech partners and research groups work with Profluent. The vendor names a strategic partnership with Eli Lilly on AI-designed recombinases worth up to $2.25 billion, and a partnership with BioMarin to design new medicines.

Profluent pricing

Profluent does not publish prices or public access terms on its homepage. Engagements are negotiated as partnerships.

Profluent alternatives

Profluent is compared with EvolutionaryScale and Chai Discovery, which also build protein foundation models. PyTorch and fast.ai are general machine learning frameworks, not protein design services.